Sr. Scientist-High Throughput Receptor Pharmacology
Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
The Lead Discovery & Optimization Group leverages technology, innovation, and broad scientific knowledge to deliver comprehensive in vitro data packages to support all phases of early drug discovery at BMS. We are seeking a highly motivated and innovative scientist to drive the development and implementation of cell-based assays supporting multiple therapeutic areas. This candidate will be expected to have a breadth of cell-based assay and in vitro pharmacology expertise to support drug discovery projects from hit identification through lead optimization.
Responsibilities:
- Collaborate closely with therapeutic area scientists to devise optimal strategies for the execution of cell-based drug discovery support within LDO.
- Ability to manage multiple projects simultaneously.
- Identify, evaluate, and implement new technologies and methods to improve upon the quality and efficiency of high-throughput receptor in vitro pharmacology HTS campaigns and SAR profiling.
- Review relevant literature and leverage knowledge to solve problems in a timely fashion.
- Identify new cell technologies and reduce them to routine practice.
- Analyze, interpret, and effectively present data at team meetings.
Basic Qualifications:
- Bachelor’s Degree 7+ years of academic/industry experience
- or
- Master’s Degree 5+ years of academic/industry experience
- or
- PhD with 2+ years of academic/industry experience
Preferred Qualifications:
- Ph.D. in pharmacology, cell biology, or related field with in-depth experience in cell-based assay design and 2+ years of experience.
- Expertise and extensive knowledge of complex cell surface receptor pharmacology including GPCR, ion channels and transporters is required.
- Extensive experience in assay design in recombinant, primary and iPSC cellular environments for hit identification, hit assessment, lead optimization and mechanism of action studies.
- Experience with immune or neuro signaling pathways a plus.
- Ability to apply new technology advances and scientific knowledge in the high-throughput screening field for drug discovery program support is required.
- Knowledge of ion flux technologies such as FLIPR and/or FDSS and high-throughput electrophysiology technologies and associated data analysis is absolutely required.
- Experience in assay miniaturization to 1536-well formats and/or acoustic liquid handlers would be seen as an advantage.
- High attention to detail, strong written and verbal communication skills, project management skills and ability to communicate scientific methods and results clearly.
- An independent, flexible and high-energy scientist.
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