Disc Medicine is a clinical-stage biopharmaceutical company committed to discovering, developing, and commercializing novel treatments for patients who suffer from serious hematologic diseases. We are building a portfolio of innovative, first-in-class therapeutic candidates that aim to address a wide spectrum of hematologic diseases by targeting fundamental biological pathways of red blood cell biology, specifically heme biosynthesis and iron homeostasis. Disc Medicine values collaboration, professional development, and scientific integrity and promotes an inclusive company culture that empowers and inspires.
POSITION OVERVIEW:
Reporting directly to the Senior Medical Director, this role offers a unique and exciting opportunity for an ambitious clinical scientist to join Disc at an inflection point of rapid growth. As a key contributor, the primary focus of this position will be supporting the company’s hepcidin suppression program. However, additional responsibilities may be tailored to the candidate’s specific interests and prior experience. The successful candidate will collaborate closely with a cross-functional program team, playing a pivotal role in advancing the clinical program from early to late-stage studies and new indications.
RESPONSIBILITIES:
- Collaborate with the Medical Director and the clinical study team in the execution of early stage, Phase 2 and pivotal clinical trials.
- Work closely with Medical Directors, Pharmacology, Innovation, external experts, and investigators to accumulate scientific and medical knowledge necessary to support clinical development plans, study designs, and protocols.
- Monitor and review safety and efficacy data in ongoing studies with the medical monitor.
- Represent the clinical study team at the clinical subteam and program team meetings.
- Collaborate with the clinical team to lead data analysis.
- Develop and maintain relationships with key opinion leaders and principal investigators.
- Lead internal and external team members, vendors, and consultants to develop, review and evaluate efficacy and safety data for regulatory submissions.
- Be responsible for the content of clinical and regulatory documents, including protocols, INDs, CTAs, investigator brochures, CRFs, annual IND reports, CSRs, and clinical expert reports.
- Organize and present at clinical advisory boards, DMC and medical/scientific meetings.
- Support business development processes for in- or out-licensing, partnering and acquisition activities.
- Travel periodically both nationally and internationally.
- Participate in Investigator meeting planning and execution and/or on-site initiation meetings.
- Maintain awareness of internal and external developments (scientific, clinical, competitive, and regulatory) including attendance at major scientific conferences, participation in competitive intelligence activities, and periodic literature review.
- Critically evaluate available information about diseases of interest to the therapeutic area and the competitive landscape while synthesizing information to support its dissemination and incorporation into clinical development, asset plans, and therapeutic area strategy.
REQUIREMENTS:
- PhD or MD with research experience.
- Ability to think strategically while executing on study responsibilities.
- Willingness to take on new responsibilities and expand professional skills and experience.
- Extensive experience in translational or clinical research related to drug development is required with biotech/pharma experience being favorably considered.
- Experience with developing clinical regulatory strategy.
- Ability to identify and build relationships with thought leaders and leading clinical centers.
- Strong academic record with high quality peer-reviewed publications that demonstrate research productivity.
- Track record of effective cross-collaboration within an organization, among teams, and external groups/organizations.
- Broad experience in clinical data analysis and presentation.
- Knowledge in the principles of clinical research methodology, statistics, data analysis and interpretation.
- Ability to clearly and effectively communicate to internal and external stakeholders orally and in writing.
- Experience in interacting with varying levels of internal/external management, academicians, clinicians, scientists, etc.
- Strong business acumen: including in-depth knowledge of the multidisciplinary functions involved in a company’s drug development process, e.g., clinical operations, biostatistics, regulatory, commercial operations, etc. and can proactively integrate multiple perspectives into the clinical development process for best end-results.
Disc Medicine is an equal-opportunity employer committed to providing all qualified candidates and employees equal opportunities. We offer comprehensive benefits and competitive compensation packages. The Company headquarters are in Watertown, MA, and we provide a flexible work environment.
Disc Medicine actively recruits individuals with an entrepreneurial spirit and a drive for excellence. Interested candidates should submit a cover letter and resume to be considered for current and future opportunities.
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