Summary:
The Ilanges lab is interested in understanding the role of the nervous system in controlling our physiological state. We are especially interested in how the nervous system can coordinate dramatic shifts in aspects of behavior, autonomic function, and metabolism during adaptive states such as our response to infection, termed sickness. To accomplish this, we use a combination of molecular and systems level approaches in both mice and zebrafish. For more information about the Ilanges lab, please visit here.
About the Role:
The lab is looking for a postdoctoral scholar with interest in neuroimmune interactions, molecular to circuit level dissection of circuits in the nervous system, neuronal control of organ function, or whole-body metabolism. The lab has ongoing projects exploring different aspects of physiology regulation with a foundation in neuroscience approaches and aided by organ function and metabolic phenotyping. Due to the nature of these projects, the lab is particularly interested in individuals willing to tackle difficult interdisciplinary projects at the interface of established fields.
Candidates with experience in molecular biology, neuronal manipulations and imaging, immunology, metabolic phenotyping (e.g. metabolomics), and electrophysiology are particularly encouraged to apply.
About the Lab:
Our lab is a part of the 4D Cellular Physiology (4DCP) research area at Janelia Research Campus. 4DCP is a broad and collaborative group focused on general principles of cell and tissue organization across systems and how the nervous system communicates with these diverse peripheral systems to coordinate bodily function. Lab members are exposed to and work closely with labs that have diverse expertise and areas of research.
What We Provide:
- A competitive compensation package, inclusive of comprehensive health and welfare benefits
- One-on-one mentorship relationship with the lab head
- Opportunities for close mentoring relationships with other group leaders and senior scientists across the Janelia Research Campus
- Generous training and travel opportunities to scientific workshops and conferences
What You'll Do:
- Handle two or more independent or collaborative research projects studying the nervous system's role in controlling diverse aspects of physiology, particularly in the infection-induced sickness state.
- Develop and test hypotheses to probe brain-body communication across scales in mice, with the potential to also work in zebrafish.
- In vivo two-photon imaging and neuronal manipulations with opto- and chemogenetic tools
- Phenotype function at the level of individual organs, metabolism using indirect calorimetry and metabolomics, and behavior
- Whole mount tissue clearing and imaging
- Single cell RNA sequencing and single cell ATAC sequencing
- Stereotactic and other forms of surgery
What You Bring:
- A Ph.D. in biology (neuroscience, molecular biology, immunology, metabolism, or related fields)
- Strong initiative, self-motivation, and capacity for creative problem solving.
- Strong verbal and written communication skills.
- Willingness to work collaboratively in a small lab environment.
Physical Requirements:
Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about the workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet).
Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis.
Please Note:
This job description sets forth the job’s principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however. Unless they begin with the word “may,” the Essential Duties and Responsibilities described above are “essential functions” of the job, as defined by the Americans with Disabilities Act.
Compensation:
An Associate 00 is compensated at a rate of $74,200.00 annually at HHMI's Janelia Research Campus.
HHMI’s salary structure is developed based on relevant job market data. HHMI considers a candidate's education, previous experiences, knowledge, skills and abilities, as well as internal equity when making job offers.
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