Lead Researcher or Senior Researcher - Tumor Cell Biology (Martine Roussel Lab)

St. Jude Children's Research Hospital (St. Jude) • Memphis, TN, United States • $200k - $250k / year • 5m ago

The Lead or Senior Researcher will play a pivotal role in the Martine Roussel Lab, conducting research focused on identifying and validating novel vulnerabilities in pediatric brain tumors. The candidate will utilize CRISPR-Cas screening techniques to explore therapeutic targets for medulloblastoma ETMR and ATRT.

The Ideal Candidate will have:

Strong experience in molecular biology techniques, including CRISPR-Cas screening, cell culture, and murine models.
Proficiency in data analysis and interpretation.
Excellent communication and collaboration skills.
Experience with neuronal tumor cell culture and orthotopic implants.
Proficiency in RNA-sequencing and other molecular biology techniques.
Strong problem-solving and analytical abilities.
Ability to work independently and as part of a team.

Job Responsibilities:

Perform CRISPR-Cas screens to identify potential vulnerabilities in pediatric brain tumors.
Culture neuronal tumor cells and conduct orthotopic implants in murine models.
Harvest tumors, extract RNA and DNA, and conduct molecular analysis (e.g., RNA-sequencing).
Contribute to the Pediatric Dependency Accelerator Project between St. Jude Children's Hospital and the Broad Institute.
Work independently within broad guidelines and subject to periodic review.
Perform laboratory experiments using existing, modified or newly developed techniques/protocols.
Set up protocols, troubleshoot experiments using new or modified laboratory techniques.
Identify experimental data pertinent to the analysis problem. Process, organize and summarize data and report results.
May assist in the drafting and editing of manuscripts.
Provide basic lab operation support including equipment maintenance and purchasing. Monitor inventory and order lab supplies as needed. Perform calibration of instruments and equipment as necessary.
Provide guidance to entry-level employees.
Perform other related duties as assigned in order to meet the goals of the department and institution.
Maintain regular and predictable attendance.

Minimum Education and/or Training:

Bachelor's degree in a relevant scientific area is required.

Lead Researcher Minimum Experience:

Five (5) years of relevant, post-degree work experience is required.
Two (2) years of relevant post-degree work experience is required with a Master's degree.
No experience is required with a PhD.

Senior Researcher Minimum Experience:

Two (2) years of relevant, post-degree work experience is required.
No experience is required with a Master's degree.

Salary range: $65,520.00/yr. - $114,400.00/yr. for Lead Researcher and $60,320.00/yr. - $105,040.00/yr. for Senior Researcher.

Compensation: In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs.

Diversity, Equity and Inclusion:

St. Jude Children’s Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world—regardless of race, religion or a family’s ability to pay.

Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success.

St. Jude is an Equal Opportunity Employer

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