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The Position
A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Roche.
Roche Sequencing Solutions (RSS), a business within Roche Diagnostics, focused on developing a disruptive Next-Generation Sequencing (NGS) platform along with a portfolio of reagents, assays and informatics solutions for multiple disease areas. We are looking for a Principal Bioinformatics Scientist in the NGS Algorithms and Applications team to support the algorithm development efforts.
In this role, you will collaborate closely with assay scientists, software engineers and other bioinformatics scientists and apply your strong knowledge in next generation sequencing technologies. This will include illumine SBS (sequencing by synthesis), nanopore, etc. to design and develop algorithms for read processing, alignment, and variant (SNV, SV, insertions/deletions, CNV, TMB, MSI) callers etc. This will be used in our products that will affect patient care.
TheOpportunity:
Lead algorithm development effort for NGS applications including conceptualization, method development and implementation of production level algorithms in an Agile environment.
Follow software development process and deliver and maintain documentation that explains why and how as well as the final design for scientific, marketing, and regulatory uses
Present internally or externally (peer-reviewed publications or conference proceedings) and communicate updates across multiple functions in the organization. Transfer algorithm to production teams and provide scientific support for updates and maintenance
Support bioinformatics pipeline to continue development for existing products.
Who YouAre:
You have a PhD in Bioinformatics, Computational Biology, Computer Science, Statistics, Mathematics or other quantitative field combined with 3+ years of industry/post-doc experience of designing novel algorithms for NGS data analysis for example read processing, variant calling (SNV, insertions/deletions, CNV, SV, TMB, MSI etc.), variant annotation and analyzing large scale complex genomic datasets.
You have 2+ years of experience in developing novel algorithms, complexity analysis, as well as demonstrated skills in statistical and mathematical modeling
You have experience implementing high-quality and efficient product level code.
You have 2+ years of experience of sequencing (long and/or short read), cancer molecular biology, bioinformatics tools, statistical methods.
You are proficient with programming languages (C++) in a distributed Linux environment
You have hands-on experience using a workflow management system such as Nextflow or Snakemake, using Docker and cloud computation resource and storage
Preferred:
The expected salary range for this position based on the primary location of Santa Clara, CA is 134,800-250,300. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
This position also qualifies for the benefits detailed at the link provided below.
Benefits
Relocation benefits are not available for this position
Who we are
At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.
Roche is an equal opportunity employer and strictly prohibits unlawful discrimination based upon an individual’s race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
