IntegerBio SeniorScientist Antibody Discovery and Protein Engineering

Workforce Genetics • Gaithersburg, MD, United States • $200k - $250k / year • 3w ago

The Opportunity: IntegerBio, a start-up biotech based in the biotech corridor of Montgomery County, Maryland, just outside Washington, DC, is building a world-class scientific team. Our company is advancing several promising assets from the lab into the clinic. Led by a team of industry veterans, we’ve set our sights on harnessing the emerging science of immunovirology and creating a future free from viral illness.

The Job: Protein Engineering and Anti-body Discovery capabilities are key to effectively prosecuting our scientific assets. The successful Scientist/Senior Scientist will bring strong technical skills, meaningful industry experience, a collaborative approach to cutting-edge scientific research and is motivated to make a meaningful impact addressing unmet medical needs.

Job Title: Scientist/Senior Scientist, Antibody/Protein Engineering

Primary responsibilities include:

Humanize antibody using CDR grafting and framework engineering.
Perform antibody affinity maturation.
Perform Fc engineering for effector function manipulation and half-life extension.
Stability engineering of antibody.
Engineer antibody mimetics.
Provide antibody developability analysis.
Execute strategies for antibody optimization efforts employing advanced molecular biology, biochemistry, cell biology techniques, protein analytics and modeling bioinformatics.
Develop process and assays to discover, generate and characterize antibodies against selected target antigens.

Requirements:

PhD in Molecular Biology, Immunology, Biochemistry or other relevant fields with 3+ years of postdoctoral experience
Experience and expertise in therapeutic antibody discovery and engineering with strong publication record.
Strong hands-on molecular biology experience is required.
Expertise in phage display and combinatory library technology.
Experience in antibody expression and purification is a plus.
Experience in mentoring, training and managing others.

IntegerBio isan equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state, or local laws.

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