Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
The Pharmaceutical Candidate Optimization organization at Bristol Myers Squibb is a dynamic, multi-disciplinary department that works to discover and optimize new drug candidates. We work across all therapeutic areas and all modalities (small molecules, biotherapeutics, gene and cell therapies and other novel modalities), and engage with all other R&D functions to advance new assets in the BMS portfolio. Our integrated, cross-functional teams apply deep expertise in drug metabolism, pharmacokinetics (DMPK), toxicology, pharmaceutics, and bioanalysis to identify and solve issues, discover high quality drug candidates, and enable their clinical development.
The successful applicant will be primarily responsible for the following:
- Enable and ensure overall high level instrument performance for bioanalysis performed on low-flow/high resolution mass spectrometers.
- Generate high quality analytical data in support of complex bioanalytical assays.
- Developing or help develop new assays for the quantification of targeted endogenous proteins in biological samples (plasma, tissue homogenates, etc.) using LC-MS in close collaboration with group members.
- Working in a team environment to optimize bioanalytical assays utilizing complex sample preparation techniques, including off-line peptide separation, immuno-precipitation, and SPE.
- Collaborating in a multidisciplinary research environment to address bioanalytical issues related to discovery programs and provide input into bioanalytical strategies.
- Representing the department on project teams and present data at internal department and/or other company meetings as well as external conferences.
- Maintaining good laboratory practices and documentation (ELN).
Basic Qualifications:- Bachelor's Degree and a 2+ years of academic or industry experience.
Preferred Qualifications:- Bachelor's Degree with 2+ years of experience or a recent Master's Degree in analytical chemistry, biochemistry or related discipline with relevant experience and emphasis on proteomics/protein quantitation and quantitative mass spectrometry.
- Hands-on experience with High-Resolution mass spectrometers (Thermo Tribrids, Exploris) and familiarity with software platforms (Protein Discoverer, Skyline, Spectronaut, etc.) is a must.
- Hands-on experience with different sample preparation procedures such as protein precipitation, immune-precipitation, liquid-liquid extraction, solid-phase extraction, etc. is preferred.
- Ability to independently diagnose and solve complex technical and scientific problems.
- Ability to troubleshoot and perform minor instrument repairs to maintain highest performance and minimize downtime, preference for technical abilities to maintain and troubleshoot low flow LC-high resolution MS systems.
- Self-motivated with excellent communication, organizational and interpersonal skills. Able to effectively manage and interface with others in a matrix team environment.
Uniquely Interesting Work, Life-changing CareersWith a single vision as inspiring as Transforming patients' lives through science, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
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