Are you a motivated bioinformatician and do you enjoy working in a diverse team? Do you want to contribute to the Princess Máxima Centre’s mission, to cure every child with cancer, with optimal quality of life? We would like to get in contact with you.
The project
As a bioinformatician, you will play a pivotal role in our ERC-funded project aimed at dissecting hematopoietic regeneration after transplantation at the single-cell level. Hematopoietic cell transplantation (HCT) is a life-saving therapy for various diseases, including leukemia. Its effect relies on donor hematopoietic stem and progenitor cells (HSPCs) to regenerate blood and immune cells in the recipient. Despite its widespread clinical use in over 40.000 patients annually, the exact mechanisms by which transplanted HSPCs regenerate blood remain unclear. Our group aims to address this question. Hereto, we apply various single-cell technologies, including single-cell RNA sequencing, CITE-seq and spatial transcriptomics, to patient-derived samples, with the ultimate goal of identifying single-cell states or trajectories that can predict HCT outcome and guide intervention.
As a bioinformatician in our group, your key responsibilities will include:
- Executing established pipelines for single-cell multi-omics (RNA, CITE-seq, single-cell WGS) and spatial transcriptomics datasets.
- Maintaining and optimizing analysis pipelines in line with the current state-of-the-art.
- Implementing novel data-analysis pipelines, particularly for spatial transcriptomics.
- Contributing to data interpretation and preparation of scientific manuscripts.
- Supporting researchers in storing, managing, archiving and sharing their research data.
Profile
We are seeking a motivated and enthusiastic Bioinformatician to join our team. Ideal candidates will possess:
- A Master’s degree in Life Sciences, Engineering, Computer Science, Information Systems, or equivalent.
- Demonstrated experience in bioinformatics.
- Experience with single-cell RNA sequencing analysis.
- Proficiency in programming languages such as R, Python and bash.
- A keen interest in translational childhood cancer research.
- Team player, who enjoys contributing to a multidisciplinary team.
- A desire to learn and adapt to new technologies and methodologies.
Our job offer
We offer a challenging position in an international, multidisciplinary research environment, which combines clinical oncology, stem cell biology and single-cell genomics. The position is based on 32 to 36 hours a week. You will initially be appointed for the duration of one year, with a possible extension. Your gross monthly salary will depend on your experience and background, starting in scale 55 with 8,33% gross monthly salary holiday allowance and 8,33 % end-of-year bonus. The Princess Máxima Center operates according to the collective labor agreement ‘cao algemene ziekenhuizen’. The starting date is flexible, with a target in Q1 of 2025.
The Belderbos lab
The Belderbos lab, established in 2020, focuses on translational hematopoietic stem cell biology. Our mission is to understand the fundamental mechanisms by which human hematopoietic stem cells regenerate blood and translate this knowledge into therapies to improve hematopoiesis in children with bone marrow failure, or in those undergoing stem cell transplantation. To achieve this mission, we employ a multidisciplinary approach, integrating single-cell technologies, in vitro assays and clinical studies in pediatric patients.
Our team consists of two postdocs, four PhD students, two wet-lab technicians and a bioinformatician. We closely collaborate with the single-cell genomics facility, with whom we have shared lab meetings, with clinicians and with several other (inter-)national research groups. Core values in our group include collaboration, curiosity and clinical impact. Our team is committed to fostering a supportive culture that encourages each team member to excel and contribute their unique talents.
The Princess Máxima Center for Pediatric Oncology is an integrated hospital and research institute, which integrates healthcare, research and education on pediatric cancer, in a single location in Utrecht. Our institute aims to provide the highest level of care for all children with cancer, with optimal quality of life. The center brings together the best possible care and scientific research, creating a unique interdisciplinary institute for pediatric oncology in Europe.
Contact
Are you our new colleague? We are looking forward to meeting you! You can apply directly by clicking on the orange button on this page. Please provide:
- A short motivation letter (maximum one A4)
- Contact information of 2-3 references
For more information about this position, or to arrange an informal chat, please contact Dr. Mirjam Belderbos . Mirjam will be happy to provide you with more information.
Acquisition as a result of this vacancy is not appreciated.
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