Job Summary
JOB SUMMARY
The Matt Bettini Lab in the Department of Pathology has an immediate opening for a Lab Specialist who shares our vision for excellence in immunology research. The position will be based at the University of Utah School of Medicine, ranked among the top 30 public research universities in the nation, located in the foothills overlooking Salt Lake City.
The focus of the available project within the broader research program is to study the role of ITAM number and sequence in Chimeric Antigen Receptor (CAR) T cell function. The Lab Specialist will have an opportunity to train in cutting-edge technologies and the use of humanized mouse models.
The Lab Specialist will contribute to projects understanding the transcriptional regulation and CAR signaling signatures of human CAR T cells in various tumor antigen models. A preferred applicant will be familiar with one or more of the following techniques: NRG / NSG mouse models and human CAR T cell generation, flow cytometry, western and IP western blots, use of next-generation single cell RNA sequencing, omics analysis including phosphoproteomics and metabolomics.
A minor component of this position will include maintenance, breeding, and genotyping a number of genetically modified mouse strains. The ideal applicant should be self-motivated and have good record-keeping and time management skills. Mouse husbandry includes maintenance, breeding, genotyping of mouse colony.
Excellent training opportunity for students interested in pursuing a career in science, including graduate and medical school.
For more information regarding the job posting, you may contact Dr. Bettini at matt.bettini@path.utah.edu, or visit https://www.bettini-lab.org.
Responsibilities
- Performs and/or directs the performance of standard and complex lab tests and experiments and/or surgical procedures for studies.
- Assists the Principal Investigator in the design, implementation and performance of new protocols and procedures as well as the modification of existing techniques.
- Reviews scientific journals, abstracts and other literature for information concerning experimental procedures.
- Makes advanced statistical calculations, analyzes data and prepares reports summarizing research results.
- Operates complex and highly specialized laboratory and surgical instruments and equipment. Instructs others in their use.
- Maintains a log of supplies used in procedures.
- May supervise, train and review the work of laboratory personnel.
- May prepare equipment and rooms for studies.
- May assist with preparing budgets.
This is an NIH-funded position. Our laboratory uses state-of-the-art approaches to interrogate how CAR ITAM sequences dictate function.
This position will give you the unique chance to actively drive research projects taking a systems biology approach for understanding CAR T cell function.
Minimum Qualifications
Bachelor’s degree in Biology, Chemistry or other scientific discipline or equivalency (one year of education can be substituted for two years of related work experience); two years full-time laboratory experience; and demonstrated human relations and effective communication skills required. Working knowledge of advanced scientific techniques and procedures as well as the ability to make statistical calculations, analyze results, prepare reports and perform specialized tests also required.
Applicants must demonstrate the potential ability to perform the essential functions of the job as outlined in the position description.
Preferences
- Applicants with expertise in CAR T cell immunology including the use of NSG / NRG mice, flow cytometry, confocal imaging, cell culture, and next generation sequencing and omics analysis are preferred.
- The ideal candidate has strong writing and organizational skills and enjoys working in a collaborative and multidisciplinary team.
- Familiarity with molecular techniques such as PCR, Flow cytometry, cell culture and general Immunology.
Additional Information
The University is a participating employer with Utah Retirement Systems (“URS”). Eligible new hires with prior URS service, may elect to enroll in URS if they make the election before they become eligible for retirement (usually the first day of work). Contact Human Resources at (801) 581-7447 for information. Individuals who previously retired and are receiving monthly retirement benefits from URS are subject to URS’ post-retirement rules and restrictions. Please contact Utah Retirement Systems at (801) 366-7770 or (800) 695-4877 or University Human Resource Management at (801) 581-7447 if you have questions regarding the post-retirement rules.
This position may require the successful completion of a criminal background check and/or drug screen.
The University of Utah values candidates who have experience working in settings with students and patients from all backgrounds and possess a strong commitment to improving access to higher education and quality healthcare for historically underrepresented students and patients.
All qualified individuals are strongly encouraged to apply. Veterans’ preference is extended to qualified applicants, upon request and consistent with University policy and Utah state law. Upon request, reasonable accommodations in the application process will be provided to individuals with disabilities.
The University of Utah is an Affirmative Action/Equal Opportunity employer and does not discriminate based upon race, ethnicity, color, religion, national origin, age, disability, sex, sexual orientation, gender, gender identity, gender expression, pregnancy, pregnancy-related conditions, genetic information, or protected veteran’s status.
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