This position is in a laboratory that studies the allosteric regulation mechanisms of protein kinases. We work with a variety of methods (EPR, NMR, x-ray crystallography, cryo-electron microscopy, FRET, etc.) to determine dynamics and structural interactions of small molecule drugs as well as binding partners of various kinases. This project would be focused under an independent grant to study the mechanism Myc transcription factor stabilization by Aurora Kinase A.
Job Responsibilities:
- 75% Research work to lead an individual project in the lab:
- Recombinantly expressing and purifying Myc transcription factors and components of the ubiquitin ligase machinery by developing new methodology
- Real-time tracking of ligand-driven allosteric structural transitions in Aurora kinases using time-resolved FRET and EPR
- Dissection of oncogenic kinase scaffolding interactions using X-ray crystallography, cryo-EM, NMR, EPR, and FRET
- Developing and optimizing new approaches for study ubiquitination patterns of Aurora kinases and Myc family transcription factors
15% Publication and presentation of data:
- Maintain accurate records
- Take the lead on completion of NIH progress reports associated with this project
- Communicate findings through publications in peer-reviewed journals
- Produce a major first author paper within the first two years of this position
- Prepare and give presentations at national and international meetings
10% Train and serve as a resource to lab members:
- Spearhead the training of junior personnel (undergraduate and graduate students, technicians) in the lab and be responsible for directing their efforts on this project
- Take the initiative on identifying new collaborators to ensure the project moves smoothly
- Foster a safe, collegial, and inclusive workplace environment
Qualifications
Required Qualifications (must be mentioned on application/resume):
- PhD in chemistry, biochemistry, or related field combined with 3+ years postdoctoral research experience
- Training in biophysical spectroscopy including electron paramagnetic resonance and ultrafast fluorescence
- Strong organizational skills, proactive, and detail orientated
- Strong written and oral communication skills
- Experience carrying out long-term projects, and contributing ideas to grant proposals
- Project management and supervision experience
- Aptitude for working in a collaborative team
Preferred Qualifications:
- Demonstrated publication record with multiple first author papers in reputable journals
- Experience with recombinant protein expression, particularly in insect cells and/or mammalian cells
- Research experience in structural biology and biophysical methods to study protein dynamics
- Ability to interact constructively with faculty and staff
- Experience training others in laboratory protocols and research methods
About the Department
The Department of Pharmacology at the University of Minnesota is one of six basic science departments in the Medical School. The well-funded research programs of our primary faculty members focus on understanding and developing better treatments for cancer, addiction and the opioid crisis, cardiovascular disease, infectious disease, and metabolic syndrome. We also offer an undergraduate Pharmacology Minor, oversee the Molecular Pharmacology and Therapeutics Graduate Program (MPaT), teach fundamental principles of pharmacology to students in professional degree programs (MD, DDS, and MD/PhD), and provide individualized training experiences for our strong community of postdoctoral scholars. Our past trainees are now applying their skills to impactful careers in academia, medicine, industry, government, law, and regulatory oversight. We are proud of our role in preparing the next generation of scientists for rewarding careers in the health sciences and related professions, and for the various other ways we give back to our community.
Benefits
Working at the University
At the University of Minnesota, you'll find a flexible work environment and supportive colleagues who are interested in lifelong learning. We prioritize work-life balance, allowing you to invest in the future of your career and in your life outside of work.
The University also offers a comprehensive benefits package that includes:
- Competitive wages, paid holidays, and generous time off
- Continuous learning opportunities through professional training and degree-seeking programs supported by the Regents Tuition Benefit Program
- Low-cost medical, dental, and pharmacy plans
- Healthcare and dependent care flexible spending accounts
- University HSA contributions
- Disability and employer-paid life insurance
- Employee wellbeing program
- Excellent retirement plans with employer contribution
- Public Service Loan Forgiveness (PSLF) opportunity
- Financial counseling services
- Employee Assistance Program with eight sessions of counseling at no cost
- Employee Transit Pass with free or reduced rates in the Twin Cities metro area
Please visit the Office of Human Resources website for more information regarding benefits.
How To Apply
Applications must be submitted online. To be considered for this position, please click the Apply button and follow the instructions. You will have the opportunity to complete an online application for the position and attach a cover letter and resume.
Additional documents may be attached after application by accessing your "My Job Applications" page and uploading documents in the "My Cover Letters and Attachments" section.
This position will remain open until filled.
To request an accommodation during the application process, please e-mail employ@umn.edu or call (612) 624-8647.
Diversity
The University recognizes and values the importance of diversity and inclusion in enriching the employment experience of its employees and in supporting the academic mission. The University is committed to attracting and retaining employees with varying identities and backgrounds.
The University of Minnesota provides equal access to and opportunity in its programs, facilities, and employment without regard to race, color, creed, religion, national origin, gender, age, marital status, disability, public assistance status, veteran status, sexual orientation, gender identity, or gender expression. To learn more about diversity at the U: http://diversity.umn.edu
Employment Requirements
Any offer of employment is contingent upon the successful completion of a background check. Our presumption is that prospective employees are eligible to work here. Criminal convictions do not automatically disqualify finalists from employment.
About the U of M
The University of Minnesota, Twin Cities (UMTC)
The University of Minnesota, Twin Cities (UMTC), is among the largest public research universities in the country, offering undergraduate, graduate, and professional students a multitude of opportunities for study and research. Located at the heart of one of the nation's most vibrant, diverse metropolitan communities, students on the campuses in Minneapolis and St. Paul benefit from extensive partnerships with world-renowned health centers, international corporations, government agencies, and arts, nonprofit, and public service organizations.
At the University of Minnesota, we are proud to be recognized by the Star Tribune as a Top Workplace for 2021, as well as by Forbes as Best Employers for Women and one of America's Best Employers (2015, 2018, 2019, 2023), Best Employer for Diversity (2019, 2020), Best Employer for New Grads (2018, 2019), and Best Employer by State (2019, 2022).
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