Job Description - Laboratory Research Technician IV (23007413)
Laboratory Research Technician IV
We are seeking a highly motivated individual for a full-time Research Specialist position in Dr. Hun-Way Hwang’s laboratory in the Department of Pathology. Our current research focuses on the role of abnormal mRNA processing in human disease. We combine powerful in vivo high-throughput profiling methods and CRISPR technology with genetically modified mouse models of human disease to identify candidate mRNA isoforms that may contribute to disease pathogenesis in specific cell types in vivo. These candidate mRNA isoforms will then be further studied by in vitro and in vivo methods to reveal their biological functions and the molecular mechanisms regulating their processing, which will provide novel insights into the management and treatment of human disease. Our two recent publications describe how cancer cells switch mRNA isoforms to survive chemotherapy (https://doi.org/10.1016/j.celrep.2021.109815) and how hyperactive mTORC1 alters mRNA isoform expression in tuberous sclerosis complex (https://elifesciences.org/articles/85036). Additional information can be found at https://www.hwangrnalab.org.
Job Summary
Performs a variety of independent and complex laboratory work and experiments. Analyzes and interprets data, compiles results, and prepares reports. Maintains inventory, ordering, and logs. Writes manuscripts and grant proposals and prepares data visualizations.
Essential Functions
- Perform mammalian cell culture and molecular biology experiments.
- Maintain day-to-day operation of the lab including preparing common lab reagents, ordering, shipping, filing inventories, tracking ongoing projects, equipment purchase/maintenance/repair, maintain IACUC and lab safety protocols.
- Optimal coordination of lab resources and experiments necessary for maximum productivity.
- Assist in mouse colonies maintenance and mouse experiments including regular visits to the mouse facility, breeding and weaning, genotyping and harvesting mouse tissues.
Physical Effort
Little physical effort required. Incumbent will be walking back and forth between various laboratory areas. Occasionally might need to lift water or buffer containers.
The University of Pittsburgh is committed to championing all aspects of diversity, equity, inclusion, and accessibility within our community. This commitment is a fundamental value of the University and is crucial in helping us advance our mission, which includes attracting and retaining diverse workforces. We will continue to create and maintain an environment that allows individuals to discover, belong, contribute, and grow, while honoring the experiences, perspectives, and unique identities of all.
The University of Pittsburgh is an Affirmative Action/Equal Opportunity Employer and values equality of opportunity, human dignity and diversity. EOE, including disability/vets.
Assignment Category: Full-time regular
Job Classification: Staff. Laboratory Research Technician IV
Job Family: Research
Job Sub-Family: Laboratory
Campus: Pittsburgh
Minimum Education Level Required: Bachelor's Degree
Minimum Years of Experience Required: 3
Will this position accept substitution in lieu of education or experience? Combination of education and relevant experience will be considered in lieu of education and/or experience requirement.
Additional details about Required Licensure/Certification: A Master's degree with three years of previous experience in a relevant field of research such as Biology, Genetics, Biochemistry or Molecular Biology.
Work Schedule: Monday - Friday; 8:30am - 5:00pm
Work Arrangement: On-Campus: Teams that work on campus, in an office, or in a lab.
Hiring Range: TBD Based Upon Qualifications
Relocation Offered: No
Visa Sponsorship Provided: No
Background Check: For position finalists, employment with the University will require successful completion of a background check.
Child Protection Clearances: Not Applicable
The University of Pittsburgh is an Affirmative Action/Equal Opportunity Employer and values equality of opportunity, human dignity and diversity. EOE, including disability/vets.
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