Your Impact:
Our In Vivo Pharmacology team is made up of collaborative, perceptive, out of the box thinkers focused on the development and execution of novel in vivo and in vitro assays. Our team partners closely with our various research teams, doing important work to support our oncology and rare disease gene therapy studies with a focus on single treatment cures for patients. In this role, you will be responsible for managing aspects of vivarium operations, leading the IVP Research and Development, and working closely with several functional areas at Poseida such as Immuno-oncology, Process Development, Translational Medicine, as well as Genetic Medicine.
Position Summary
The In Vivo Pharmacology Associate Director (IVP AD) is a laboratory-based position. The incumbent will be responsible for the management, design, and execution of research and pre-clinical studies in support of Poseida Therapeutics' portfolio of cell and gene therapy products. It is expected that the IVP AD is innovative and has deep knowledge of cellular and molecular immunology with a robust background in animal models of disease to evaluate the basic biologic components associated with CAR-T and gene therapies, enabling the identification of potential therapeutic benefits or risks. Furthermore, the candidate will be part of a collaborative team that develops, implements, and supports in vivo platforms focused on reproducible, high quality, and robust drug discovery experimental procedures.
Responsibilities
These may include but are not limited to:
- Manage, develop, and implement reproducible and high-quality animal models for the determination and evaluation of CAR-T, gene therapies, and other areas to meet Poseida's portfolio.
- Lead, develop, and execute in vivo product screening in support of product development.
- Oversee and perform molecular biology assays such as production of CAR-T cells, flow cytometry, ELISA, and immunohistochemistry.
- Work collaboratively with research teams to identify possible toxicology effects and therapeutic strategies.
- Critically review and analyze data, communicate results, and troubleshoot preclinical research accordingly.
- Prepare study protocols, experiment reports, as well as QA/QC and regulatory documents.
- Perform study protocol tasks including (but not limited to) xenografts, dosing, data acquisition, data recording, and data analysis.
- Train staff in diverse techniques in vivo and in vitro.
Requirements, Knowledge, Skills and Abilities
- Ph.D. in a Scientific discipline with at least 8+ years relevant experience preferred. Master's or Bachelor's degree with at least 10 years of relevant industry experience.
- Extensive experience in in vivo pharmacology, animal model development, and cell therapy.
- Experience with xenograft tumor models required.
- Experience in genetic animal models a plus.
- Proficient in small animal survival surgeries for more than one therapeutic area is a plus.
- Proficiency in laboratory bench skills such as multi-color flow cytometry, ELISAs, Luminex, western blots, IHC, BLI, molecular biology for CAR-T production.
- Analytical methods for functional characterization of T cells such as activation, cytotoxicity, cytokine secretion, and proliferation.
- Ability to analyze data and synthesize information from various disciplines into an experimental design and execution.
- Proficiency in culture of primary and immortalized mammalian cells.
- Excellent scientific capability demonstrated by scientific accomplishments such as publications, invited presentations, etc.
- Experience in working and leading teams in a collaborative interdisciplinary environment.
- Excellent organizational skills, ability to multi-task.
- Demonstrated ability to work effectively in a dynamic, complex, and fast-paced team environment.
- Ability to travel between Poseida facilities as well as to the vivarium.
Salary Range
Associate Director, In Vivo Pharmacology Salary Range is: $149,000 to $186,000. The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type and length of experience with the industry, education, geographic location, etc.
Who We Are and What We Do
Based in San Diego, Poseida Therapeutics is a clinical-stage biopharmaceutical company utilizing our unique and proprietary genetic engineering platform technologies to create next-generation cell and gene therapies with the capacity to cure. We are passionate about making an impact on patients' lives with the development of our CAR-T therapies in various cancers and gene therapies for rare diseases. Our goal is to deliver potential single treatment cures for patients in need. Our portfolio of product candidates is specifically designed to overcome the limitations of current generation cell and gene therapeutics.
At Poseida, we put people first. Our team is passionate about improving patients' lives through innovation. See what our team has to say about our culture:
"My favorite part about Poseida is all the people that I get to work with. Everyone is so passionate about what we're doing here and there's so much camaraderie. It feels like one big enthusiastic family."
"My favorite part about working at Poseida is the amazing culture and working environment. Everybody is friendly, professional, collaborative, and has a remarkable can-do and positive attitude."
As we advance our compelling pipeline, there are endless opportunities for impact and growth. We encourage you to apply today!
Recruitment Fraud Alert
Alert: Beware of Employment Scams. Poseida Therapeutics, Inc. has received reports of employment-related scams. These scams have appeared in forms of false job advertisements and/or unsolicited contacts via communication/chat platforms, phone, email or text from individual(s) claiming to be or represent Poseida's Human Resources team. Be advised that Poseida Therapeutics does not extend unsolicited employment offers. Furthermore, Poseida Therapeutics does not request payment information or charge prospective employees with any fees during the recruitment process.
If you would like to pursue employment opportunities with Poseida Therapeutics, Inc., please visit our official careers website https://poseida.com/careers-culture/ or official Poseida Therapeutics LinkedIn page. Job postings that do not link directly to our careers website or official Poseida LinkedIn page are not legitimate and might be fraudulent. You may report fraudulent job advertisements or contacts via our Contact Us page at https://poseida.com/contact-us/ and select the subject "Careers." If you have been defrauded or suspect identity theft as a result of an employment scam, please contact your local law enforcement agency for guidance.
