The Company
Verve is a clinical-stage genetic medicines company established with a mission to solve the global health epidemic of cardiovascular disease. Founded by world-leading experts in cardiovascular medicine, human genetics and gene-editing, Verve is pioneering a new approach to the care of cardiovascular disease, potentially transforming treatment from chronic management to single-course gene editing medicines. The company's initial three programs – VERVE-101, VERVE-102, and VERVE-201 – target genes that have been extensively validated as targets for lowering low-density lipoprotein cholesterol (LDL-C), a root cause of cardiovascular disease. VERVE-101 and VERVE-102 are designed to permanently turn off the PCSK9 gene in the liver and are being developed initially for heterozygous familial hypercholesterolemia (HeFH) and ultimately to treat atherosclerotic cardiovascular disease (ASCVD) patients not at goal on oral therapy. VERVE-201 is designed to permanently turn off the ANGPTL3 gene in the liver and is initially being developed for homozygous familial hypercholesterolemia (HoFH) and ultimately to treat patients with refractory hypercholesterolemia. In 2023, Verve was named a Top Place to Work by The Boston Globe for the third consecutive year. Verve is headquartered in Boston, Massachusetts.
The Position
Verve is seeking a Senior Research Associate/Research Associate in Cell Biology and Potency Analytics to support analytical method development and testing of mRNA and gRNA oligonucleotide drug substances and drug products across all stages of development. This individual will be working in a cross-functional team to design, develop and qualify phase appropriate bioassays to support Verve's growing gene editing pipeline. The position will be part of an integrated project team that aims to advance preclinical gene editing candidates into the clinic and work closely with discovery, process development and internal quality control groups.
Job Responsibilities
- Collaborate across multiple cross-functional teams to perform experiments and summarize work in presentations and technical reports.
- Draft analytical test methods, maintain equipment and order critical reagents.
- Develop and apply cell-based potency assays, immunoassays, and other state of the art technologies to analyze and characterize cell and gene products.
- Author Standard Operating Procedures (SOPS), test methods, and generate qualification protocols and reports.
- Other duties as assigned.
Qualifications
- B.S. degree in biological sciences / pharmaceutical sciences or related scientific concentration. (3+ years of related experience for Senior Research Associate level).
- Previous experience in gene therapy method development and/or qualification is a plus.
- Knowledge/hands-on experience in cell biology techniques and assays are a plus, but not required.
- Ability to work effectively on cross-functional teams with a willingness to roll-up-sleeves to get things done.
- Excellent interpersonal and collaborative skills, and the ability to work independently and effectively in a highly dynamic environment.
- Comfortable communicating highly technical information.
- Strong attention to detail, critical analysis of data/reports, and sound troubleshooting abilities.
Verve Therapeutics is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. If you have a disability or special need that requires accommodation, please let us know.
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