Job Description Summary
Location: San Diego, CA
About the role:
We are seeking a highly skilled and motivated Research Scientist I to join our dynamic in vitro pharmacology team in San Diego dedicated to advancing gene therapy and siRNA for neurological and neuromuscular diseases. As a key member of our research team, you will play a critical role in supporting various aspects of research including tissue sample processing, biodistribution, biomarker assay development, antibody screening campaigns, as well as oversee lab operation activities. Join us in our mission to transform the treatment landscape for neurological and neuromuscular diseases through cutting-edge gene therapy approaches. Apply now to make a meaningful impact on the lives of patients worldwide!
Your Key Responsibilities:
- Cross-program molecular biology support, including biodistribution studies, quality control work to validate reagents, vectors, and construct design.
- Conduct tissue sample processing techniques for DNA, RNA, and protein isolation for downstream analysis.
- Execute gene expression analysis utilizing techniques such as RT-/ddPCR ELISA assays, RNAseq library preparation, and additional molecular biology work as assigned.
- Support in vitro bioassays development in engineered cell lines, and disease-relevant in vitro systems.
- Provide administrative and operational support for the In Vitro Pharmacology team, including procurement, online database maintenance, and lab management activities.
- Plan, execute, and analyze experiments under supervision while maintaining contemporaneous and detailed documentation of results.
- Manage interactions with vendors.
- Help to maintain and ensure a safe laboratory environment and good laboratory practices.
- Collaborates across a dynamic and cross-functional scientific environment.
Role Requirements:
Essential Requirements:
- B.S. in molecular biology, cell biology, biochemistry, bioengineering, or related scientific discipline and 0+ years experience.
- Experience with basic molecular biology techniques, including cloning, DNA/RNA isolation, PCR.
- Experience with basic protein assay methods, including Western blot and ELISA.
- Experience with basic cell biology techniques, including aseptic cell culture, cell counting, cell banking.
- Experience in gene therapy and biodistribution methods a plus.
- Adept at learning new techniques quickly.
- Strong organizational skills and work ethics.
Desirable Requirements:
- Prior experience in gene therapy research, particularly in neurological and neuromuscular diseases.
- Demonstrated ability to work in a fast-paced and growing team environment and to prioritize work from multiple projects.
- Must be highly reliable and goal/deadline oriented.
- Hands-on experience with automation and high-throughput screening platforms, a plus.
Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients' lives. Ready to create a brighter future together?
Benefits and Rewards: Read our handbook to learn about all the ways we'll help you thrive personally and professionally.
Commitment to Diversity & Inclusion: The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.
Accessibility and reasonable accommodations: The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to tas.nacomms@novartis.com and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
Salary Range: $80,000.00 - $120,000.00
Skills Desired: Analytical Skill, Analytical Thinking, Biology, Chemistry, Clinical Pharmacology Skills, Collaboration, Communication Skills, Data Analysis, Decision Making, Design Of Experiments, Detail-Oriented, Ethics, Hypothesis Testing, Laboratory, Lifesciences, Medical Research, Organization, Pain Management, Pharmacology, Problem Solving Skills.
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