Lycia Therapeutics, Inc. is a biotechnology company leveraging its lysosomal targeting chimera (LYTAC) platform from Founder and Chemistry Nobel Laureate 2022, Carolyn Bertozzi, to discover and develop first-in-class therapeutics that degrade extracellular and membrane-bound proteins. Lycia’s next generation degraders harness the cell’s endogenous lysosomal trafficking and degradation machinery with the potential to degrade targets previously considered to be intractable, across a spectrum of indications. After raising $105 million in capital in 2021, Lycia is advancing an internal pipeline of novel degraders and has entered a strategic collaboration with Eli Lilly to address key unmet medical needs. In May 2024, Lycia Therapeutics completed a $106.6 million series C financing to advance its pipeline of LYTAC extracellular protein degraders to the clinic. Lycia is headquartered in South San Francisco.

Visit https://lyciatx.com/ for more information.

The Role:

The lab manager will partner with research staff, purchasing, and building facilities personnel and will serve as the main point of contact for issues relating to lab operations and safety. The ideal candidate will be self-directed, organized, a strong communicator and will work collaboratively with laboratory members to support all aspects of laboratory research operations.

Key Responsibilities

Onsite management of the day-to-day operation and maintenance of the biology, biologics, chemistry and communal laboratory spaces to ensure a safe and efficient workplace.
Oversee inventory management, operation of laboratory equipment, waste disposal and assist with requisitioning for all lab members.
Be the point person for maintenance and compliance with all laboratory safety policies and regulations.
Organization of laboratory consumables - Responsible for procurement, storage, organization, inventory and replenishment of shared lab consumables.
Receiving – daily delivery of shipments from loading dock to the intended recipient, check contents, and submit packing slips.
Shipping - Support preparation of outgoing domestic and international shipments to vendors and collaborators (e.g. FedEX, World Courier).
Manage equipment maintenance, calibration, and repair: Coordinate with research personnel to implement service contracts, repairs, calibrations, certifications, and preventative maintenance. Coordinate annual biosafety cabinet and fume hoods recertification.
Waste management: Manage biohazard and chemical waste streams including labeling, waste disposal pick-ups and waste manifest record keeping and reporting. Update hazardous waste profiles. Chemical waste inventory prep for disposal and manifest signing. Annual renewal/update of EPA, biohazardous & hazardous permits and Hazardous Materials Business Plan.
Oversee maintenance and resupply of lab gases, including CO2 and liquid nitrogen. Biweekly NMR Nitrogen fill.
Manage purchasing & installation of key equipment and labware (e.g. refrigerators, freezers, glassware, storage racks/bins, etc).
Chemical inventory management and internal chemistry compound registration (e.g. maintaining SDS records, updating and maintaining inventory database).
-80C freezer defrosting/cleanouts/reorganization and maintenance of freezer maps.
Coordinate annual lab safety trainings and onboarding of new lab members.
Routine lab safety monitoring - serve as a lab safety officer, monitor laboratory environment to ensure compliance according to SOPs. Attend lab safety committee meetings.
Other duties as assigned.

Requirements:

BA/BS or MS degree and minimum of 3-5 years of experience working in an industry lab environment.
Knowledge of general laboratory equipment and ability to troubleshoot problems.
Experience with safety regulations/inspections and lab waste management.
Organized and detail-oriented with meticulous record keeping.
Highly motivated, with excellent interpersonal and communication skills.

Compensation:

$95,000 - $125,000 a year

The expected base salary range for this role is $95,000 - $125,000. We encourage candidates of all levels to apply as there is often flexibility on job title and responsibilities. Compensation will be based on a variety of factors, including experience, qualifications and internal equity. Lycia offers a competitive employment package that includes an annual bonus, equity, and a generous benefits package.

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

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Lycia Therapeutics

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Laboratory Manager